RELATIONSHIP OF HYPERKALEMIC RESPONSE TO HEPATIC PHOSPHORYLASE ACTIVATION INDUCED BY ADRENALINE

[摘要] References(20)Cited-By(3)Experiments were undertaken to disclose the relation of hepatic release of potassium induced by adrenaline to glycogenolytic action.1. In fasted dogs hepatic glycogen concentration was markedly and phosphorylase level slightly lower than in normal dogs, whereas potassium concentration of liver, serum potassium and blood glucose concentrations were unchanged.2. Hyperglycemia, hyperkalemia and liver phosphorylase activation induced by adrenaline were reduced respectively by 58%, 40% and 35% in fasted dog as compared with normal dog.3. Increase in phosphorylase activity, reduction of potassium in the liver and increase in serum potassium occurred synchronously in rapid time course.

[学科分类] 药理学