The Effect of Mesoporphyrin on the Production of Cytokines by Inflammatory Cells In Vitro

[摘要] References(46)Cited-By(1)This study was conducted to investigate a mechanism of the anti-inflammatory action of mesoporphyrin, especially the effect on the production of cytokines by some cultured inflammatory cells. Mesoporphyrin had no effect on lipopolysaccharide-induced tumor necrosis factor-α production by RAW 264.7 cells (murine macrophage-like cells). Mesoporphyrin inhibited interferon-γ production by 1E10.H2 cells (murine T helper-1 cells), but not interleukin-4 production by D10.G4.1 cells (murine T helper-2 cells). Mesoporphyrin inhibited interleukin-6 production by human osteoblast-like MG-63 cells. This inhibition of interleukin-6 production is closely related to the suppression of prostaglandin E2 generation by interfering cyclooxygenase 1 and 2 enzyme activities. These data suggest that the inhibition of cytokine production is one of the anti-inflammatory mechanisms of mesoporphyrin.

[学科分类] 药理学

[关键词] Mesoporphyrin;Interferon-γ;Cyclooxygenase activity