Effects of β-Blockers and Nicardipine on Oxotremorine-Induced Tremor in Common Marmosets

[摘要] References(15)Effects of β-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. Generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. Intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. The total intensity of oxotremorine-induced tremor for each drug was expressed as “points”, which were the sum of tremor intensity scores evaluated every 10 min up to 190 min following the administration of oxotremorine. β-Blockers significantly suppressed the tremor. On the other hand, the Ca2+ channel blocker exacerbated the tremor.

[学科分类] 药理学

[关键词] Oxotremorine-induced tremor;β-Blocker;Ca2+ channel blocker