Activation of In Vivo Kupffer Cell Function by Oral Administration of Cordyceps sinensis in Rats

[摘要] References(15)Cited-By(23)We investigated the effect of water extracts of Cordyceps sinensis (WECS) on Kupffer cell function in rats. Rats were received a single i.v. injection of a colloidal carbon solution and then the clearance rate from the blood were measured. The rats had been daily administered with WECS, p.o. at a dose of 200 mg/kg for 25 days until the day before the injection of colloidal carbon. The half-life of the colloidal carbon in the blood of rats administered WECS 200 mg/kg was significantly shorter than that of the control rats. This suggests that accelerated function of Kupffer cells is partially involved in the anti-metastatic action of WECS.

[学科分类] 药理学

[关键词] Water extract of Cordyceps sinensis (WECS);Kupffer cell function;Colloidal carbon