Inhibitory Effect of KBT-3022, a New Anti-platelet Agent, on Infiltration of Polymorphonuclear Leukocytes Induced by Leukotriene B4 or Formyl-Methionyl-Leucyl-Phenylalanine in Mice

[摘要] References(15)Cited-By(1)We devised a method for evaluating polymorphonuclear leukocyte (PMN) infiltration in vivo employing an air bleb technique combined with measurement of myeloperoxidase (MPO) activity, and the effects of some anti-platelet agents were evaluated. KBT-3022 (ethyl 2-[4, 5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate) and cilostazol inhibited the increase in MPO activity in the connective tissue around the air bleb induced by leukotriene B4 (LTB4) and formyl-methionyl-leucyl-phenylalanine (fMLP). Indomethacin inhibited only the fMLP-induced increase in MPO activity, but ticlopidine hydrochloride and acetylsalicylic acid had no effect. Histologic observation confirmed the inhibition of PMN infiltration by KBT-3022. These results indicate that KBT-3022 may be a potent inhibitor of both LTB4- and fMLPinduced infiltration of PMNs.

[学科分类] 药理学

[关键词] Leukotriene B4;Formyl-methionyl-leucyl-phenylalanine;KBT-3022