Cardiac Hypertrophy-Related Gene Expression in Spontaneously Hypertensive Rats: Crucial Role of Angiotensin AT1, Receptor

[摘要] References(16)Cited-By(6)Angiotensin converting-enzyme inhibitors (alacepril and imidapril) or an AT1, -receptor antagonist (SC-52458) was administered to 10-week-old spontaneously hypertensive rats (SHR) for 7 days, and cardiac mRNA levels for contractile proteins and atrial natriuretic polypeptide (ANP) were comprehensively measured. The expression of skeletal α-actin and ANP was selectively enhanced in the heart of vehicle-treated SHR compared with Wistar-Kyoto rats (WKY), thereby suggesting that the phenotypic modulation of myocytes occurred at the early stage of hypertension. The above-mentioned three drugs similarly suppressed these enhanced gene expressions, nearly to the control levels. In contrast, although the treatment with hydralazine lowered the blood pressure of SHR similarly, hydralazine did not suppress ANP expression at all and only partially suppressed skeletal α-actin. Moreover, alacepril did not affect these gene expressions in WKY. Thus, AT1, receptor may be crucial for phenotypic modulation in the heart of SHR.

[学科分类] 药理学

[关键词] Spontaneously hypertensive rat;Cardiac phenotype;Renin-angiotensin system