Inhibitory Action of Nebracetam on Various Stimuli-Evoked Increases in Intracellular Ca2+ Concentrations in Cultured Rat Cerebellar Granule Cells

[摘要] References(15)Cited-By(5)Nebracetam (10-100 μM) dose-dependently inhibited increases in intracellular Ca2+ concentrations evoked by various stimuli in cultured rat cerebellar granule cells. The magnitude of the nebracetam (100 μM)-induced inhibition of L-glutamate- and N-methyl-D-aspartate-evoked Ca2+ responses was 1.5-fold and 1.7-fold greater, respectively, than the inhibition of the high K+-evoked response. These findings suggest that in cultured cerebellar granule cells, nebracetam attenuates the external Ca2+ influx derived from the activation of N-methyl-D-aspartate receptor-gated rather than voltage-gated Ca2+ channels.

[学科分类] 药理学

[关键词] Intracellular Ca2+ concentration;Cerebellar granule cell (cultured)