Effects of KCA-012 on Bone Metabolism in Organ Culture

[摘要] References(12)Cited-By(2)3, 9-Dihydroxy-5H-benzofuro[3, 2-c]quinoline-6-one (KCA-012), the chemical structure of which is closely similar to that of the phytoestrogen coumestrol, inhibited parathyroid hormone-, 1α, 25-dihydroxyvitamin D3- and prostaglandin E2-induced bone resorption of cultured fetal rat bones. KCA-012 also increased the calcium content of 9-day chick embryonic femur cultured in vitro. KCA-012 did not show any estrogenic activity as determined by an increase in the uterine weight of ovariectomized rats, whereas coumestrol did. These results indicate that KCA-012 has no estrogenic activity and has unique effects of inhibiting bone resorption and stimulating bone mineralization.

[学科分类] 药理学

[关键词] KCA-012;Bone resorption;Bone mineralization