Effects of Talipexole on Contraversive Rotation and Functional Impairment in MPTP-Induced Chronic Hemiparkinsonian Monkeys

[摘要] References(17)Cited-By(3)The effects of talipexole on functional motor improvement in comparison with contraversive circling were studied in five chronic (5 - 7 years post MPTP-lesioned) hemiparkinsonian Macaca nemestrina monkeys. Talipexole induced contraversive rotations in a dose of 32 μg/kg for about 1 hr after i.m. injection. Larger doses (56 and 100 μg/kg, i.m.) produced less effect due to sedation. Three different rating scales were used to assess functional improvement, including a clinical parkinsonism rating scale, volitional responses to fruit presentations, and number of significant hand movements. The optimal dose of talipexole was 32 μg/kg, i.m. Functional improvement by talipexole, including clinical parkinsonian rating scales and significant hand movements, as well as contraversive circling in hemiparkinsonian monkeys, confirm that this chronic animal model is useful in preclinical testing of drugs for the treatment of human parkinsonism.

[学科分类] 药理学

[关键词] Talipexole;MPTP;Chronic hemiparkinsonism (monkey);Functional improvement;Dopamine D2-like receptor agonist