Induction of CPP32-Like Activity and Inhibition of Interleukin 1β Converting Enzyme Activity in the Liver of a Mouse Concanavalin A-Induced Hepatitis Model

[摘要] References(13)Cited-By(2)The objective of the present study was to determine the effects of concanavalin A (Con A) administration on the interleukin 1β converting enzyme (ICE) activity and CPP32-like activity in mouse liver. Treatment with Con A (0.2 mg/mouse, i.v.) caused an elevated plasma alanine aminotransferase (ALT) level at 8 hr after Con A injection. ICE activity was decreased at 8 and 24 hr after Con A treatment. In contrast, CPP32-like activity was increased at 24 hr after Con A injection. Since CPP32-like activity was induced after ALT had increased, the induction of CPP32-like activity may not be involved in Con A-induced hepatitis.

[学科分类] 药理学

[关键词] Concanavalin A;Interleukin 1β converting enzyme;CPP32