Effect of KW-8232, a Novel Anti-osteoporotic Agent, on Bone Loss in Sciatic Neurectomized Rats

[摘要] References(10)Cited-By(1)The purpose of this study was to evaluate the effects of 3-[bis(4-hydrozuphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1-ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW-8232 on bone resorption in this animal model. Male Sprague-Dawley rats underwent unilateral hind-limb immobilization by sciatic neurectomy. KW-8232 (3, 10 and 30 mg/kg, p.o.) was effective in inhibiting femoral bone loss. KW-8232 decreased urinary pyridinoline and deoxypyridinoline excretion. These results indicate that KW-8232 effectively prevents the bone loss due to immobilization.

[学科分类] 药理学

[关键词] KW-8232;Bone loss;Sciatic neurectomy