Effect of Tazarotene, an Acetylenic Retinoid, on Human Dermal Fibroblast

[摘要] References(14)Cited-By(4)The inhibitory effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast in vitro was compared to that of all-trans-retinoic acid. The proliferation of fibroblasts was inhibited by both retinoids at the concentration of 1 μM after 5 days of culture. Synthesis of DNA and collagen was inhibited by both retinoids concentration-dependently up to 10 μM, although tazarotene was weaker in the inhibition of collagen synthesis. These results suggest the possible usefulness of tazarotene in the treatment of fibrotic diseases.

[学科分类] 药理学

[关键词] Tazarotene;Dermal fibroblast;Collagen