EFFECTS OF DIURETICS ON CALCIUM EXCRETION AND Ca2+-ACTIVATED ATPase IN RAT KIDNEY

[摘要] References(17)Cited-By(7)Effects of three diuretics on the urinary Ca2+ excretion and on the microsomal Ca2+-activated ATPase were examined in the rat kidney. Furosemide and bumetanide increased Na+, K+, and Ca2+ excretion in the rats. Acetazolamide increased Na+ and K+ excretion but not Ca2+. Urinary inorganic phosphate excretion was not affected during the administration of acetazolamide. It is suggested that acetazolamide inhibits Na+ transport without affecting Ca2+ reabsorption in the rat nephron. Microsomal ATPase of the rat kidney cortex was stimulated by Ca2+ or Mg2+ alone and an additive effect of the two cations was not observed. Microsomal ATPase activated by Ca2+ or Mg2+ was not inhibited by furosemide, bumetanide, and acetazolamide. These data suggest that the inhibitory effect of furosemide and bumetanide on the Ca2+ reabsorption is not related to the inhibition of Ca2+-activated ATPase.

[学科分类] 药理学