POTENTIATION OF THE NGF-MEDIATED NERVE FIBER OUTGROWTH BY GINSENOSIDE Rb, IN ORGAN CULTURES OF CHICKEN DORSAL ROOT GANGLIA

[摘要] References(17)Cited-By(19)The fiber outgrowth induced by ACh, dibutvryl cyclic AMP and dibutyryl cyclic GMP in explanted chick embryonic dorsal root ganglia differed distinctly from that by nerve growth factor (NGF) and submandibular gland extract of adult male mice. Ginsenoside Rb1 potentiated the effects of NGF and submandibular extract at concentrations of 3 and 30 μM. but did not potentiate the effects of ACh, dibutyryl cyclic AMP and dibutyryl cyclic GMP. NGF-antihody inhibited the effects of NGF, but not the effects of ACh, dibutyryl cyclic AMP and dibutvryl cyclic GMP. Concanavalin A and KCL did not promote fiber outgrowth.

[学科分类] 药理学