Effects of RS-8359 on Reduced Local Cerebral Glucose Utilization in the Rat Subjected to Transient Forebrain Ischemia

[摘要] References(22)Cited-By(3)Changes in local cerebral glucose utilization (LCGU) of the postischemic rat brain were investigated using the rat four-vessel occlusion model. Following 20 or 30 min of ischemia, LCGUs of the cerebral cortices, striatum and hippocampus were decreased at 1 and 3 days postischemia, but were recovered at 7 days postischemia. Effects of repeated administration of RS-8359, (±)-4-(4-cyanoanilino)-7-hydroxycyclopenta(3, 2-e)pyrimidine, (30 mg/kg × 2/day, p.o., 4 days) were examined at 3 days postischemia following 20 min of ischemia. Compared with the sham-operated group, the LCGUs of 22 out of 34 structures examined in the ischemic-control group were significantly reduced. In the RS-8359-treated group, however, significant reduction was observed in only 9 structures. Compared with the ischemic-control group, RS-8359 significantly ameliorated the reduction of LCGU in 12 structures. These results suggest that RS-8359 has beneficial effects on reduced glucose metabolism in the postischemic brain.

[学科分类] 药理学

[关键词] RS-8359;Ischemia (rat brain);Local cerebral glucose utilization (LCGU)