Susceptibility to Adenosine Agonists of Giant Migrating Contractions Induced by Glycerol Enema in Anesthetized Rats

[摘要] References(15)Cited-By(4)The present study examined whether adenosine agonists influence the occurrence of giant migrating contractions (GMCs) induced by glycerol enema (65%, 2 ml/kg) in rats. Catheter pressure transducers were used to measure the colonic luminal manometric alterations. The adenosine A1 agonists (2S)-N6-(2-endo-norbornyl)adenosine ((S)-ENBA) (10 μg/kg, i.v.) and N6-cyclohexyladenosine (30 μg/kg, i.v.) abolished the GMCs, whereas the adenosine A2 agonist 2-[p-(2-carboxyethyl)phenethylamino]-5''-N-ethylcarboxamidoadenosine (CGS 21680) (30-300 pg/kg, i.v.) failed to influence the GMCs. The suppressive action of (S)-ENBA on the GMCs was entirely counteracted by the peripheral adenosine antagonist 8-(p-sulfophenyl)theophylline (10 mg/kg, i.v.). The present observations suggest that the adenosine A1 agonist suppresses the GMCs via peripheral adenosine receptors.

[学科分类] 药理学

[关键词] Adenosine agonist;Glycerol;Giant migrating contraction