Fenamates Potentiate the α1-Adrenoceptor-Activated Nonselective Cation Channels in Rabbit Portal Vein Smooth Muscle

[摘要] References(10)Cited-By(6)The agonistic action of fenamates on the α1-adrenoceptor-activated cationic current (Icat) in rabbit portal vein smooth muscle was investigated with the whole-cell patch clamp technique. At −50 mV, the fenamates (100-500 μM) increased Icat dose-dependently, up to several fold. This increase was not accompanied by changes in the reversal potential and strongly inhibited by 500 μM Cd2+ or 10 mM procaine. The enhancing effect of fenamates was also observed on the cationic current activated by intracellularly applied GTPγS. These results suggest that fenamates may be useful as a new class of activator for receptor-operated cation channels in smooth muscle.

[学科分类] 药理学

[关键词] Cation channel opener;Smooth muscle;Fenamate