Altered Prostaglandin Metabolism Induced by Angiotensin-Converting Enzyme Inhibitors in Broncho-Alveolar Lavage Fluid of the Guinea Pig

[摘要] References(24)The aim of this study was to investigate if prostaglandin (PG) metabolism is altered by angiotensin-converting enzyme (ACE) inhibitors as determined in the broncho-alveolar lavage fluid (BALF) of the guinea pig. Enalapril or imidapril was orally administered once a day for 2 weeks to Hartley male guinea pigs. Twenty-four hours after the last treatment, BALF was collected and the concentrations of PGI2, thromboxane A2 (TXA2) and PGE2 were measured by enzyme immunoassay. Enalapril significantly (P2 content, which was inhibited by indomethacin treatment and significantly (P2 content. Imidapril, however, did not affect TXA2 or PGI2generation. These findings suggest that altered PG metabolism may be associated with coughing as a side effect of enalapril.

[学科分类] 药理学

[关键词] Imidapril;Angiotensin-converting enzyme inhibitor;Broncho-alveolar lavage fluid;Thromboxane A2;Prostacyclin