Effect of Terfenadine and KW-4679, a Novel Antiallergic Compound, on Action Potential of Guinea Pig Ventricular Myocytes

[摘要] References(15)Cited-By(5)It has been reported that terfenadine caused torsade de pointes ventricular arrhythmias. The prolongation of action potential duration (APD) in ventricles is considered to be one of the mechanisms of this adverse effect. We examined the effect of antiallergic drugs, terfenadine and KW-4679 ((Z)-11[3-(dimethylamino)propylidene]-6, 11-dihydrodibenz[b, e]oxepin-2-acetic acid hydrochloride), on action potentials in isolated guinea pig ventricular myocytes. Terfenadine (30 nM-1 μM) increased APD in a concentration-dependent manner. On the other hand, KW-4679 (0.1 μM-100 μM) exerted no significant effects on action potential parameters. These results present no evidence that KW-4679 has the possibility to cause ventricular arrhythmias.

[学科分类] 药理学

[关键词] Antiallergic drug;Action potential;Ventricular myocyte