Betaxolol, αβ1-Adrenoceptor Antagonist, Inhibits Ca2+-Induced Contraction in Skinned Renal Artery of the Dog

[摘要] References(12)Cited-By(5)The effects of betaxolol on Ca2+-induced contractions in saponin-treated skinned canine renal arteries were examined. Betaxolol decreased the pCa (-log[Ca2+] M) 5.8-induced contraction at the same concentrations at which the drug relaxed the high K+-induced contraction in intact smooth muscles. The pCa-tension relation was shifted to the right and downward by betaxolol. Betaxolol inhibited the increase in Cat+-induced contraction by calmodulin, and this effect of betaxolol was observed even at the concentration that had no effect when given alone. These results suggest that betaxolol decreases the Ca2+ sensitivity of the contractile system in skinned canine renal arteries, presumably by inhibiting calmodulinmediated contractions.

[学科分类] 药理学

[关键词] Betaxolol;Ca2+ sensitivity;Skinned smooth muscle