Menadione Toxicity in Cultured Rat Cortical Astrocytes

[摘要] References(19)Cited-By(32)We examined the effect of menadione on the morphology and viability of cultured astrocytes. Exposure of astrocytes to menadione induced a progressive cell death. The toxic effect of menadione was concentration- and time-dependent. Menadione toxicity was blocked by antioxidants, superoxide dismutase, catalase and iron chelators, indicating that superoxide anions (02¯), hydrogen peroxide (H202) and hydroxyl radicals (''OH) are all involved in menadione toxicity. Menadione cyiotoxicity should be useful as a model for studying the mechanisms underlying oxidative injury in the brain and for the screening of drugs that may attenuate cell damage caused by oxidative stress.

[学科分类] 药理学

[关键词] Menadione;Toxicity;Reactive oxygen species;Astrocyte;Culture