A Potent Mu-Opioid Receptor Agonist, Dihydroetorphine, Fails to Produce the Conditioned Place Preference in Mice

[摘要] References(15)Cited-By(6)Reinforcing effects of dihydroetorphine (DHE) and morphine were evaluated by the conditioned place preference paradigm. Both DHE and morphine produced an antinociceptive effect in a dose-dependent manner. On the other hand, DHE (0.1, 1, 3 and 10 μg/kg, i.p.) failed to induce the conditioned preference, while morphine (0.1, 1, 3 and 10 mg/kg, i.p.) caused a dose-dependent preference for the drug-paired place. Thus, these characteristic properties of DHE make it attractive for development as a novel potent analgesic compound that has less dependence liability.

[学科分类] 药理学

[关键词] Dihydroetorphine;Morphine;Conditioned place preference