Effect of the Selective Adenosine A1-Receptor Antagonist KW-3902 on Tubuloglomerular Feedback in Radiocontrast-Media-Induced Nephropathy in Rats With Chronic Nitric Oxide Deficiency

[摘要] References(15)Cited-By(1)To study the possible mechanism of renoprotective effects of adenosine A1-receptor antagonist against radiocontrast media (RCM)-induced nephropathy, we investigated the effects of adenosine A1-receptor antagonist on tubuloglomerular feedback (TGF) activity prior to and following application of RCM in chronic NO-depleted rats. TGF in NO-depleted rats was significantly enhanced compared with that in normal rats. After RCM application, the enhanced TGF was continued. A selective adenosine A1-receptor antagonist, KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), inhibited the enhanced TGF. These results suggest that KW-3902 could inhibit TGF in chronic NO-depleted rats. Renoprotective effects by adenosine antagonists could be partly due to an inhibition of TGF via the blockade of the adenosine A1-receptor.

[学科分类] 药理学

[关键词] Contrast media;Adenosine;Tubuloglomerular feedback