2-Bromoethylamine, a Suicide Inhibitor of Tissue-Bound Semicarbazide-Sensitive Amine Oxidase

[摘要] References(10)Cited-By(6)Various mammalian tissues contain plasma membrane−bound amine oxidase, termed semicarbazide−sensitive amine oxidase(SSAO).In the present study, 2−bromoethylamine has been studied with regard to inhibitory properties towards tissue−bound SSAO in rat lung.Without preincubation, 2−bromoethylamine was a competitive and reversible SSAO inhibitor with a Ki value of 2.5 μM.After preincubation, it time−dependently and non−competitively inhibited SSAO activity, probably by forming the covalently−bound enzyme−inhibitor adduct.The data presented suggest that 2−bromoethylamine may act as a suicide inhibitor of SSAO.

[学科分类] 药理学

[关键词] Semicarbazide-sensitive amine oxidase(SSAO);2-Bromoethylamine(2-BEA);Suicide inhibitor