Ca2+-Independent Phospholipase A2 Inhibitor Impairs Spatial Memory of Mice

[摘要] References(9)Cited-By(19)Pharmacological blockade of Ca2+−independent phospholipase A2(PLA2)is reported to disintegrate hippocampal synaptic plasticity, which is thought to be the cellular mechanism underlying learning and memory.Therefore, we investigated the effect of the Ca2+−independent PLA2 inhibitor bromoenol lactone(BEL)on spontaneous alteration behaviors of mice.When 3 nmol BEL was intracerebroventricularly injected 30 min prior to the test, the mice showed a poor alternation ratio, compared with control animals.The data suggest that Ca2+−independent PLA2 activity is required for spatial memory.

[学科分类] 药理学

[关键词] Phospholipase A2;Learning and memory;Spontaneous alternation behavior