Effects of Intraplantar Morphine in the Mouse Formalin Test

[摘要] References(13)Cited-By(4)We studied the effects of intraplantar morphine in the formalin test in mice.Intraplantarly administered morphine(30−300μg)induced analgesic effects at lower doses than intraperitoneally administered morphine.Following the administration of [3H]morphine, the % of radioactivity present in brain was the same by either route.In contrast, higher radioactivity values appeared in the injected paw in those mice intraplantarly injected.Since local morphine induces analgesia at doses lower than the intraperitoneally administered drug, especially in the second phase of the test, and the access to brain is undistinguishable, we propose that local morphine enhances central opiate analgesia in the formalin test in mice.

[学科分类] 药理学

[关键词] Peripheral analgesia;Intraplantar morphine;Formalin test