SK4 Encodes Intermediate Conductance Ca2+-Activated K+ Channels in Mouse Urinary Bladder Smooth Muscle Cells

[摘要] References(10)Cited-By(16)The single channel current of intermediate conductance Ca2+−activated K+ channel(IK channel)was measured in mouse urinary bladder myocytes(MBM), and the molecular basis of the channel was suggested to be the SK4 subtype by RT−PCR.Among Ca2+−activated K+ channel subtypes(SK2, SK3, SK4 and BK), the mRNAs of SK4 and BK were predominantly expressed in MBM.IK channel currents recorded from MBM showed:38.7 pS slope conductance under symmetrical 140 mM K+ conditions, Ca2+−dependent activation, and blockade by charybdotoxin and econazole.These results strongly suggest that SK4 encodes IK channels in MBM.

[学科分类] 药理学

[关键词] Intermediate conductance Ca2+-activated K+(IK)channel;SK4;Bladder smooth muscle