Molecular Basis of Spatio-temporal Dynamics in Inositol 1, 4, 5-Trisphosphate-Mediated Ca2+ Signalling

[摘要] References(41)Cited-By(11)Inositol 1, 4, 5−trisphosphate(IP3)−mediated Ca2+ signalling regulates many important cell functions, and the spatio−temporal dynamics of the Ca2+ signalling is a crucial factor for its versatility.The molecular mechanisms that control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns.I also discuss the spatio−temporal dynamics of intracellular IP3 concentration, describing recent methodological advances in monitoring intracellular IP3 concentration.These findings highlight the potential importance of the spatio−temporal information of any signalling molecule.

[学科分类] 药理学

[关键词] Ca2+ wave;Ca2+ oscillation;Inositol 1;4;5-trisphosphate receptor;Phospholipase C