Effect of Zaldaride Maleate, an Antidiarrheal Compound, on 16, 16-Dimethyl Prostaglandin E2-Induced Intestinal Ion Secretion in Rats

[摘要] References(15)The effect of zaldaride, a calmodulin inhibitor, on 16, 16−dimethyl prostaglandin E2(dmPGE2)−induced intestinal ion secretion was investigated in rats.Zaldaride inhibited the dmPGE2−induced increase in water content in the colon, but not that in the small intestine.In the colonic mucosa, zaldaride attenuated the dmPGE2−induced short−circuit current;however, it did not affect the forskolin or dibutyryl cAMP−induced effect.These results suggest that zaldaride inhibits dmPGE2−induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin−dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.

[学科分类] 药理学

[关键词] Zaldaride maleate;Calmodulin;Intestinal secretion