Interaction of Bradykinin with Substance P on Vascular Permeability and Pain Response

[摘要] References(7)Cited-By(15)Combination of bradykinin with substance P exerted synergistic effects on vascular permeability and pain response in mouse paw. Denervation of sciatic nerve reduced significantly bradykinin-induced vascular permeability, suggesting the involvement of sensory nerves. The bradykinin-induced vascular permeability was also reduced by intravenous injection of a substance P-antagonist. The results suggest that neuronal substance P takes part in the action of bradykinin on inflammation and pain sensation.

[学科分类] 药理学