In Vivo Voltammetric Study of Dopamine Release in the Striatum Following Microinjection of Apomorphine into the Substantia Nigra Zona Reticulata

[摘要] References(35)Cited-By(4)Effect of microinjection of apomorphine into the substantia nigra zona reticulata (SNP, ) on the dopamine (DA) release in the ipsilateral striatum was examined in the present study. To measure the DA release, we determined DA and/or DOPAC levels in the striatum by using in vivo voltammetry. The microinjection of apomorphine (10 μg/2 μl) into the SNR produced a rapid and prolonged increase in the DA and/or DOPAC peak in the ipsilateral striatum. These results suggest that release of DA from dendrites of DA cells normally plays a physiological role in the SNR neurons.

[学科分类] 药理学