DIFFERENTIAL SUSCEPTIBILITY OF L CELLS IN THE EXPONENTIAL AND STATIONARY PHASES TO CADMIUM CHLORIDE

[摘要] References(15)Cited-By(5)Comparative studies of the cellular toxicity and uptake of cadmium in L cells in the exponential and stationary phases were done. The LD50 of cadmium chloride to L cells in the exponential and stationary phases was 5.5 and 30.5 μM, respectively and the cadmium content of L cells exposed to 5.5 μM cadmium chloride for 3.5 hr in the exponential and stationary phases was 0.123 and 0.065 μg 106 cells, respectively. These results suggest that the higher susceptibility of cells in the exponential phase to cadmium may be caused by an increased permeability of the cell membrane to cadmium.

[学科分类] 药理学