ALLOMETRIC METHOD FOR THE LONG TERM OBSERVATION OF ADJUVANT ARTHRITIS IN RATS

[摘要] References(5)An allometric method for estimating the volume change in inflamed paw of rats is described. The technique is effective and advantageous for long term observation of adjuvant arthritis which lacks a suitable reference criterion due to the simultaneous swelling of the control paw. In the present method, the inflammatory intensity (IF) of paw edema is estimated by means of the formula: IF(%)={2Vt/cXd(I÷Wt/aXb)-I}×100 where Vt is the paw volume, Wt is the body weight and X is the tail length of the inflamed rat. The constants a, b, c and d are obtained from the normal rats using the relative growth law, W=aXb and V cXd (where W is the body weight, V is the paw volume and X is the tail length).

[学科分类] 药理学