EFFECTS OF La+++, Mn++ AND RUTHENIUM RED ON Mg·Ca-ATPase ACTIVITY AND ATP-DEPENDENT Ca-BINDING OF THE SYNAPTIC PLASMA MEMBRANE

[摘要] References(22)Cited-By(7)The effects of La+++, Mn++ and ruthenium red (R.R.) on Ca-uptake of synaptic plasma membranes (S.P.M.) were investigated. La+++ (0.1 mM), Mn++ (0.2 mM) and R.R. (0.1 mM) selectively inhibited Mg·Ca-ATPase but did not significantly affect Mg-ATPase activity. The apparent Ki values of La+++, Mn++ and R.R. for Mg·Ca-ATPase were 0.05, 0.06 and 0.03 mM, respectively. La+++, Mn++ and R.R. did not affect Ca-uptake at concentrations which strongly inhibited Mg·Ca-ATPase activity. These results indicate that Ca-uptake by S.P.M. differs from that by sarcoplasmic reticulum.

[学科分类] 药理学