A Comparison of the Effects of Estradiol and 2 and 4-Hydroxyestradiol on Uterine Ornithine Decarboxylase Activity in Immature Rats

[摘要] References(15)Cited-By(5)Effects of estradiol (E2)and catechol-estrogens (CEs: 2-OHE2 and 4-OHE2)on uterine ornithine decarboxylase (ODC)activity have been compared in immature rats. The intensity of their actions by s.c. (1μg)and intrauterine right-horn (i.u., 25 ng)injection was in the order of: 4-OHE2≥ E2 > 2-OHE2. Although i.u.-injection of E2 caused an increase in ODC activity in the left (intact)-horn, which was about 60% that of the right-horn, the effects by CEs were limited only to the right-horn. The results are consistent with the previous view about the order of the potency of 4-OHE2 and 2-OHE2 and also suggest that locally produced CEs may play a role in the physiological functions of the production site.

[学科分类] 药理学

[关键词] Estradiol;2-and 4-Hydroxyestradiol;Uterine ornithine decarboxylase activity