L-Dopa Potentiates Presynaptic Inhibitory α2-Adrenoceptor but Not Facilitatory Angiotensin II Receptor-Mediated Modulation of Noradrenaline Release from Rat Hypothalamic Slices

[摘要] References(15)Cited-By(4)L-Dopa is a potentiator for presynaptic β-adrenoceptors. We studied whether L-dopa potentiates the activities of other presynaptic receptors to modulate the evoked noradrenaline (NA) release in rat hypothalamic slices. UK14304 (0.1-1 μM), a selective α2-agonist, concentration-dependently inhibited NA release. Noneffective 10 pM L-dopa potentiated the UK14304-induced inhibition. This potentiation was selectively antagonized by 1 nM L-dopa methyl ester, a competitive L-dopa antagonist, while yohimbine antagonized both the inhibition by UK14304 alone and its potentiation by L-dopa. However, 10 pM L-dopa produced no effect on angiotensin II (0.1-1 nM)-induced facilitation. L-Dopa potentiates activities of presynaptic β- and α2-adrenoceptors but not those of angiotensin II receptors on rat hypothalamic NA neurons.

[学科分类] 药理学

[关键词] DOPA (endogenous neuroactive substance);Presynaptic α2-adrenoceptor;Noradrenaline release (rat hypothalamic slices)