Expression and Functional Characterization of a Rat Sulfotransferase (ST1A1)cDNA for Sulfations of Phenolic Substrates in COS-1 Cells

[摘要] References(15)Cited-By(12)A cDNA (PST-1)isolated from a rat liver cDNA library was expressed in COS-1 cells and found to encode a form of arylsulfotransferase (termed ST1A1), which sulfated p-nitrophenol, α-naphthol, minoxidil, β-estradiol and dopamine, but not dehydroepiandrosterone and cortisol. ST1A1 showed a mobility identical with a major immunodetectable sulfotransferase contained in the livers of male and female rats in Western blots. In addition, ST1A1 mRNA was detected in the liver and extrahepatic tissues by Northern blots.

[学科分类] 药理学

[关键词] Sulfotransferase;Sulfation (dopamine and minoxidil);Arylsulfotransferase (ST1A1)