Central α2-Adrenoceptor-Mediated Inhibition of Gastric Motility in Rats

[摘要] References(9)Cited-By(5)We investigated the subtype of α-adrenoceptors participating in central noradrenergic inhibition of gastric motility in urethane-anesthetized rats. Noradrenaline at 10 nmole administered intracisternally (i.c.) significantly decreased gastric motility. Yohimbine at 10 nmole, i.c., but not the same dose of prazosin, abolished this noradrenaline-induced decrease in gastric motility. Clonidine at 10 nmole, i.c., but not phenylephrine at 20 nmole, significantly decreased gastric motility. These results suggest that α2-adrenoceptor-mediated mechanisms in the brain stem are involved in noradrenergic inhibitory regulation of gastric motility.

[学科分类] 药理学

[关键词] Central α2-adrenoceptor;Gastric motility