SCH 23390 Equivalently, but YM-09151-2 Differentially Reduces the Stimulant Effects of Methamphetamine, MK-801 and Ketamine: Assessment by Discrete Shuttle Avoidance in Mice

[摘要] References(15)Cited-By(4)The inhibitory actions of the selective dopamine D1 and D2-antagonists SCH 23390 and YM-09151-2, respectively, on the mouse''s discrete shuttle avoidance were almost equipotent at doses ranging from 0.01-0.1 mg/kg. SCH 23390 reduced the stimulant action of methamphetamine (0.5 mg/kg), MK-801 (0.1 mg/kg) and ketamine (10 mg/kg) with a similar potency. YM-09151-2 also antagonized the actions of these drugs, with the following order of effectiveness: ketamine > MK-801 > methamphetamine. The present results indicate that methamphetamine, MK-801 and ketamine have different characteristics of CNS stimulant action through dopamine D2-receptors.

[学科分类] 药理学

[关键词] Dopamine D1- and D2-antagonists;Stimulant;Discrete shuttle avoidance