EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATI OF ALIPHATIC DIAMINES ON INGESTIVE BEHAVIOR IN THE RAT

[摘要] References(42)We examined the pharmacological effects of intracerebroven-tricularly administered aliphatic diamines on ingestive behavior in male rats adapted to a 4 hr per day feeding and drinking schedule. 1, 2-Ethanediamine (ETD), 1, 3-propanediamine (PRD), 1, 4-butanediamine (putrescine, PUT), 1, 5-pentanediamine (cadaverine, CAD) and 1, 6-hexanediamine (HED) suppressed feeding and drinking behavior in a dosedependent manner, but not unless a relatively high dose (over 80 μg) was given. The approximate anorectic potency was HED>CAD=PUT> ETD>PRD. A sedation was also produced in fairly good parallel to these alterations in feeding and drinking behavior. Thus, there appears to be a relationship between the length of the carbon chain and the potency of the pharmacological action, and these inhibitory effects on feeding and drinking behavior are probably not due to a specific action on the regulatory system for ingestive behavior, but rather to a nonspecific action.

[学科分类] 药理学