Tizanidine May Discriminate between Imidazoline-Receptors and α2-Adrenoceptors

[摘要] References(10)Cited-By(17)The selectivity of tizanidine to the imidazoline-receptor and α2-adrenoceptor recognized by 3H-p-aminoclonidine was examined in rat kidney membranes and was compared with those of other imidazoline compounds. Tizanidine bound to the imidazoline-receptors with approximately 20 times higher affinity than the α2-adrenoceptors. The order of relative selectivity to imidazoline receptor was tizanidine > oxymetazoline > clonidine > naphazoline, where clonidine showed an equal affinity to both receptors. Tizanidine may act more potently on the imidazoline-receptors than the α2-adrenoceptors.

[学科分类] 药理学

[关键词] Tizanidine;Imidazoline-receptor;α2-Adrenoceptor;Kidney (rat)