Sialogogic Effects on Rat Submandibular Gland of Analogs of the C-Terminal Hexapeptide of Substance P

[摘要] References(15)The sialogogic response of submandibular glands to analogs of the C-terminal hexapeptide of substance P with various amino acids at the N-terminus was investigated in urethane-anesthetized rats. The rank order of potencies was as follows: SP > (pGlu6)SP6-11 >> (Dab6)SP6-11 > (Orn6)SP6-11 > (Gln6)SP6-11 > (Lys6)SP6-11 >> (Ala6)SP6-11. These results suggest that the sialogogic activity of the analogs of the C-terminal hexapeptide is influenced by the steric effects of the N-terminal amino acid, and the nature of its side chain is of particular importance.

[学科分类] 药理学