Amphetamine-Antagonistic Property of 4-Phenyltetrahydroisoquinoline: Effect on Noradrenaline Release in Spinal Cord Slices

[摘要] References(19)Cited-By(4)The amphetamine-related compounds methamphetamine, phenylethylamine and nomifensine increased the K+-evoked release of endogenous noradrenaline from rat spinal cord slices. 4-Phenyl-1, 2, 3, 4-tetrahydroisoquinoline (4PTIQ), which alone did not affect the K+-evoked release of noradrenaline, inhibited the noradrenaline-releasing effects of methamphetamine, phenylethylamine and nomifensine. 4PTIQ revealed a weak noradrenaline-uptake inhibitory effect, and the effect was weaker than those of desipramine and nomifensine. These results showed that 4PTIQ is an antagonist against the amine-releasing effects of amphetamines.

[学科分类] 药理学

[关键词] 4-Phenyl-1;2;3;4-tetrahydroisoquinoline;Methamphetamine;Noradrenaline release;Spinal cord