Tryptophan Inhibits the [3H]Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA

[摘要] References(14)We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.

[学科分类] 药理学

[关键词] Glutamate uptake;Brain mRNA;Xenopus oocytes