Effect of Dibutyryl Cyclic AMP-Treatment on Prostaglandin F2a-Stimulated Phosphoinositide Hydrolysis in Cultured Rat Astrocytes

[摘要] References(12)Cited-By(7)Dibutyryl cyclic AMP (dBcAMP)-treatment of cultured rat astrocytes induced changes in astrocyte morphology followed by the potentiation of prostaglandin F2α (PGF2α)-stimulated phosphoinositide (PI) hydrolysis. The potentiation was observed in astrocytes of the cerebral cortex, cerebellum, and hippocampus. The dBcAMP-treatment induced agonists-specific changes in PI hydrolysis; e.g., the potentiation of norepinephrine-effect and the reduction of the carbachol-effect. Coincubations of carbachol or norepinephrine with PGF2α produced additive responses.

[学科分类] 药理学