Effects of Nitric Oxide-Related Compounds and Carperitide on Hemodynamics and Hematocrit in Anesthetized Rats

[摘要] References(15)Cited-By(1)Sodium nitroprusside, nitroglycerin and carperitide (α-human ANP) all reduced mean blood pressure, but only carperitide increased the hematocrit in rats with bilateral renal artery- and ureter-ligation. NG-Monomethyl L-arginine, a selective inhibitor of nitric oxide synthesis, elevated the mean blood pressure but did not change the hematocrit significantly. These findings suggest that ANP has a physiological role in regulating circulatory blood volume distinct from that of NO, although both increase intracellular cyclic GMP in the vasculature.

[学科分类] 药理学

[关键词] Atrial natriuretic peptide;Nitric oxide;Hematocrit