Selectivity of Bevantolol Hydrochloride towards α- and β-Adrenoceptor Subtypes in Rat Cerebral Cortex

[摘要] References(15)Cited-By(3)Selectivity of bevantolol hydrochloride (NC-1400) towards α- and β-adrenoceptor subtypes of rat cerebral cortex was examined in binding experiments and compared with propranolol. Bevantolol biphasically displaced the 3H-dihydroal-prenolol binding. The affinity of bevantolol to β1-adrenoceptor was equal to that of propranolol. Bevantolol displaced 3H-prazosin binding monophasically but not 3H-p-aminoclonidine binding. These results suggest that bevantolol is a β1-adrenoceptor antagonist with a relatively high affinity to α1-adrenoceptor subtypes.

[学科分类] 药理学