Effect of Ketotifen on Acute Gastric Lesions and Gastric Secretion in Rats

[摘要] References(10)Cited-By(5)Ketotifen, a histamine H1-receptor antagonist and mast cell stabilizer, significantly protected the rat gastric mucosa against lesions induced by necrotizing agents, histamine or compound 48/80. The agent significantly inhibited the basal gastric acid secretion, but had little or no effect on the histamine-stimulated secretion. The mucosal protective effect was observed even at a dose that had little or no effect on gastric acid secretion, suggesting that ketotifen exhibits so-called cytoprotective activity.

[学科分类] 药理学

[关键词] Ketotifen;Acute gastric lesions;Cytoprotection