Dibutyryl Cyclic AMP and Forskolin Inhibit Phosphatidylinositol Hydrolysis, Ca2+ Influx and Contraction in Vascular Smooth Muscle

[摘要] References(10)Cited-By(20)Dibutyryl cyclic AMP and forskolin inhibited the contraction induced by norepinephrine (NE) more strongly than the high K+-induced contraction in isolated rat aorta. These inhibitors inhibited the 45Ca2+ influx stimulated by NE but not that by high K+, and they inhibited NE-induced inositol monophosphate accumulation. These results suggest that cAMP inhibits NE-induced contraction, at least partly, by inhibiting the α-adrenoceptor-mediated signal transduction and high K+-induced contraction by decreasing Ca2+ sensitivity but not Ca2+ influx.

[学科分类] 药理学

[关键词] cyclic AMP;Phosphatidylinositol turnover;Vasodilation