MK-801 Prevents the Post-Ischemic Cerebral Hypoperfusion, but Not the Dysfunction of the Vagal Baroreflex in Dogs

[摘要] References(11)Cited-By(3)Pretreatment with MK-801, a non-competitive N-methyl-D-aspartate (NMDA) antagonist, failed to protect the vagal component of reflex bradycardia from 5-min global cerebral ischemia in dogs under pentobarbital anesthesia. On the other hand, MK-801 completely prevented the development of the post-ischemic cerebral hypoperfusion without affecting the cerebral blood flow in sham-operated animals. The results suggest that NMDA receptors may participate in the development of the secondary disturbance of the cerebral circulation, but are not involved in the post-ischemic dysfunction of the baroreflex system.

[学科分类] 药理学

[关键词] Cerebral ischemia;Baroreflex;MK-801